Fig. 2. Behavioural assessment anxiety and locomotor activity. Behavioural analysis after MCAo: Elevated Plus Maze test (time in open arms A and number of entries B), Open Field (time in the centre C and number of crossing D). Behavioural analysis after TBI: Elevated Plus Maze test (time in open arms E and number of entries F), Open Field (time in the centre G and number of crossing H). *p <0.05 vs sham young; **p <0.01 vs sham young;***p <0.001 vs sham young; ##p <0.01 vs sham old; ###p <0.001 vs sham old; ° p <0.05 vs TBI young.